Order number AK1603-S 100 assays
The AKCELL BRCA1 AK™PCR Mutation Screen Kit is designed to screen for the mutations on the on the BRCA1, commonly associated with breast cancer, ovarian cancer, male breast cancer, prostate cancer and pancreatic cancer. BRCA1 Mutations and Cancer
BRCA1 and BRCA1 (/ˌbrækəˈwʌn/) are a human gene and its protein product, respectively. The official symbol (BRCA1, italic for the gene, nonitalic for the protein) and the official name (breast cancer 1) are maintained by the HGNC. Orthologs, styled Brca1 and Brca1, are common in other mammal species. BRCA1 is a human tumor suppressor gene (to be specific, a caretaker gene), found in all humans; its protein, also called by the synonym breast cancer type 1 susceptibility protein, is responsible for repairing DNA.
BRCA1 and BRCA2 are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA, or destroy cells if DNA cannot be repaired. They are involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double-strand breaks. If BRCA1 or BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer.
Equipment Compatible with ABI 7500 Real-Time Systems or equivalent. Intended Use AKCELL’s BRCA1 mutation screen reagents are provided for research use only (RUO).
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