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Order number AK1603-S 100 assays

The AKCELL BRCA1 AK™PCR Mutation Screen Kit is designed to screen for the mutations on the on the BRCA1, commonly associated with breast cancer, ovarian cancer, male breast cancer, prostate cancer and pancreatic cancer.
BRCA1 Mutations and Cancer

BRCA1 and BRCA1 (/ˌbrækəˈwʌn/[1]) are a human gene and its protein product, respectively. The official symbol (BRCA1, italic for the gene, nonitalic for the protein) and the official name (breast cancer 1) are maintained by the HGNC. Orthologs, styled Brca1 and Brca1, are common in other mammal species.[1] BRCA1 is a human tumor suppressor gene[2][3] (to be specific, a caretaker gene), found in all humans; its protein, also called by the synonym breast cancer type 1 susceptibility protein, is responsible for repairing DNA.[4]

BRCA1 and BRCA2 are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA, or destroy cells if DNA cannot be repaired. They are involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double-strand breaks.[5][6] If BRCA1 or BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer.[7][8]

Equipment
Compatible with ABI 7500 Real-Time Systems or equivalent.
Intended Use
AKCELL’s BRCA1 mutation screen reagents are provided for research use only (RUO).

1- Hamel PJ (2007-05-29). “BRCA1 and BRCA2: No Longer the Only Troublesome Genes Out There”. HealthCentral. Retrieved 2010-07-02.

2- Duncan JA, Reeves JR, Cooke TG (October 1998). “BRCA1 and BRCA2 proteins: roles in health and disease”. Molecular pathology : MP 51 (5): 237–47.

3- Yoshida K, Miki Y (November 2004). “Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage”. Cancer science 95 (11): 866–71.

4- Check W (2006-09-01). “BRCA: What we know now”. College of American Pathologists. Retrieved 2010-08-23.

5- Friedenson B (August 2007). “The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers”. BMC Cancer 7: 152–162.

6- Friedenson B (2008-06-08). “Breast cancer genes protect against some leukemias and lymphomas.

7- “Breast and Ovarian Cancer Genetic Screening”. Palo Alto Medical Foundation. Archived from the original on 4 October 2008.

8- Friedenson B (2007). “The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers”. BMC Cancer 7: 152.